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In dieser Rubrik beantworten wir Fragen, die uns zu den SANUM-Arzneimitteln und deren Verordnung gestellt werden.


» Questions concerning products
Does the product Citrokehl contain natural citric acid?

Citric acid is produced by a submerged fermentation process which employs a strain of the micro-organism Aspergillus niger to convert sugar into citric acid. The substrate (carbohydrates like sugar or glucose syrup and certain inorganic nutrients) is sterilized and inoculated with Aspergillus niger for fermentation. The fungus produces citric acid by metabolization of the substrate in a self contained tank (fermentation). The fungus releases the citric acid into the tank. After the fermentation the biomass and the citric acid are separated. The separation can be effected in two different ways.

Process A) The citric acid is recovered from the remaining broth by an adsorption process. The resulting citric acid solution is purified by ion exchange and carbon treatment. Finally the citric acid solution is evaporated, and citric acid is crystallized, dried, sieved and packaged.

Process B) The dissolved citric acid is separated from residual sugars, proteins and other soluble impurities by addition of lime. The resulting calcium citrate precipitate is separated and washed free of soluble impurities. The calcium citrate then is acidified with sulphuric acid resulting in citric acid solution and calcium sulphate (gypsum). After the separation of gypsum the citric acid solution is purified by ion exchange and carbon treatment. Finally the citric acid solution is evaporated, and citric acid is crystallized, dried, sieved and packaged.

The borderline from natural source to synthetic is fluid. However, based on the above stated manufacturing process, it can be stated that the citric acid used for Citrokehl originates from natural sources.


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